• Reduces number of animals used
  • Minimizes compound requirements
  • Generates more reliable results

For efficacy and PK studies researchers often rely on terminal blood sampling in mice, where each mouse provides only a single blood draw. With NoAb's cannulated mouse model, our highly skilled surgeons implant cannulae in the jugular vein and carotid artery of the mouse. Using state-of-the-art automated blood sampling equipment, blood samples are collected serially from each freely-moving mouse, without the use of swivels or anaesthesia, and with volume replacement at each time point.

NoAb's cannulated mouse model offers:

  • A blood/plasma concentration vs. time curve from each individual mouse
  • Automated sampling, reducing stress on the animals and eliminating the possible confounding effects of anaesthesia
  • 80-90% less compound and animals used per study (assuming 6 cannulated mice = 48 terminal collection mice)
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